Histocompatibility antigens on murine tumors.

Abstract

Recent advances in tumor immunology suggest that the expression of the histocompatibility antigens, encoded by the major histocompatibility complex, is important in controlling the metastatic growth of certain murine tumors. The anomalous expression of histocompatibility antigens in many neoplasms appears to be associated with the ability of these cells to evade the immune system and progress to metastasis. This review examines some of the underlying molecular and immunobiological interactions that might determine the metastatic outcome of cellular transformation.

• Authors: R S Goodenow, J M Vogel, R L Linsk
• Journal: Science (New York, N.Y.) (Science) Vol. 230 Issue 4727 Pg. 777-83 (Nov 15 1985) ISSN: 0036-8075 [Print] United States
• PMID: 2997918 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA, Neoplasm
• H-2 Antigens
• Histocompatibility Antigens

Topics

• AKR murine leukemia virus
• Animals
• Cricetinae
• DNA, Neoplasm (genetics)
• H-2 Antigens (immunology)
• Histocompatibility Antigens (genetics)
• Humans
• Leukemia Virus, Murine (genetics)
• Leukemia, Experimental (genetics, immunology)
• Major Histocompatibility Complex
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Neoplasm Transplantation
• Neoplasms (genetics, immunology)
• Neoplasms, Experimental (genetics, immunology)
• Neoplasms, Radiation-Induced (genetics, immunology)
• Rats
• Retroviridae (genetics)
• T-Lymphocytes, Cytotoxic (immunology)