Abstract | BACKGROUND/AIM: MATERIALS AND METHODS: Serum samples were collected for routine biochemical studies from 55 patients with NAFLD patients and from 50 healthy individuals. Class I and II ADH and ALDH activity were measured by spectrofluorometric method. Photometric methods were used to measure ADH class III, IV and total ADH activity. RESULTS: Total ADH activity was significantly higher in non- alcoholic fatty liver (NAFL) and non- alcoholic steatohepatitis (NASH) than in healthy individuals (44 and 48.5% activity, respectively). The median total activity of ADH was 1,164 mU/l in patients with NAFLD, 1,258 mU/l in NASH and 648 mU/l in the control group. The increase in ADH class I and II isoenzyme in serum of patients with NAFL and NASH was statistically significant. The activity of ADH I, ADH II, and total ADH significantly increased with increasing disease progression. CONCLUSION:
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Authors | Wojciech Jelski, Blanka Wolszczak-Biedrzycka, Elżbieta Zasimowicz-Majewska, Karolina Orywal, Tadeusz Wojciech Lapinski, Maciej Szmitkowski |
Journal | Anticancer research
(Anticancer Res)
Vol. 38
Issue 7
Pg. 4005-4009
(Jul 2018)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 29970524
(Publication Type: Journal Article)
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Copyright | Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Chemical References |
- Isoenzymes
- Alcohol Dehydrogenase
- Aldehyde Dehydrogenase
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Topics |
- Adult
- Aged
- Alcohol Dehydrogenase
(blood)
- Aldehyde Dehydrogenase
(blood)
- Case-Control Studies
- Female
- Humans
- Isoenzymes
(blood)
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(enzymology)
- Spectrometry, Fluorescence
- Young Adult
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