Involvement of bicuculline-insensitive receptors in the hypothermic effect of GABA and its agonists.

Abstract

GABA, delta-aminovaleric acid (DAVA) and sodium valproate (VPA) decrease core temperature in conscious rats. Bicuculline increases GABA-induced hypothermia, does not modify DAVA (250 mg/kg) and VPA (100 and 400 mg/kg) hypothermia and antagonizes initial hypothermia by DAVA (1000 mg/kg) and VPA (200 mg/kg) and late hypothermia by DAVA (500 mg/kg) and VPA (200 mg/kg). Picrotoxin increases late hypothermia by GABA (250 mg/kg) and VPA (400 mg/kg), but decreases initial hypothermia by VPA (200 mg/kg). Pentylenetetrazol increases variably GABA-induced hypothermia, inhibits early early hypothermia by DAVA and increases hypothermia induced by VPA (400 mg/kg). We conclude that GABA and GABA-agonists (DAVA and VPA) may induce hypothermia partly mediated by activation of bicuculline-insensitive GABA-receptors.

• Authors: J S Serrano, F J Miñano, M Sancibrián, J A Durán
• Journal: General pharmacology (Gen Pharmacol) Vol. 16 Issue 5 Pg. 505-8 ( 1985) ISSN: 0306-3623 [Print] England
• PMID: 2996972 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Amino Acids, Neutral
• Receptors, GABA-A
• Picrotoxin
• gamma-Aminobutyric Acid
• Valproic Acid
• 5-aminovaleric acid
• Pentylenetetrazole
• Bicuculline

Topics

• Amino Acids (pharmacology)
• Amino Acids, Neutral
• Animals
• Bicuculline (pharmacology)
• Body Temperature (drug effects)
• Drug Interactions
• Female
• Hypothermia (chemically induced)
• Pentylenetetrazole (pharmacology)
• Picrotoxin (pharmacology)
• Rats
• Rats, Inbred Strains
• Receptors, GABA-A (drug effects)
• Time Factors
• Valproic Acid (pharmacology)
• gamma-Aminobutyric Acid (pharmacology, physiology)