Abstract |
The effect of neuropeptides and their analogs on anoxia-induced amnesia was examined using one-trial passive avoidance task in mice. Anoxia, produced by the exposure to CO2 immediately after the acquisition of avoidance response, induced amnesia which is shown by a short latency to enter from the safety compartment into the shocked compartment in the retention test conducted 24 hr later. In these anoxia-treated animals, thyrotropin-releasing hormone (TRH: 10-20 mg/kg), its analog DN-1417 (10-20 mg/kg) and ACTH 4-10 (66 micrograms/body), which were given sc 15-60 min before the retention test, markedly prolonged the latency in a dose-dependent manner, indicating a reversal of the amnesia. Arginine- and lysine-vasopressin also reversed the amnesia at a dose of 100 micrograms/body. These results suggest that TRH and DN-1417, known to reverse the amnesia produced by the protein synthesis inhibitor cycloheximide, have ameliorating effects on the retrieval process of memory.
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Authors | N Yamazaki, M Shintani, Y Saji, Y Nagawa |
Journal | Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology
(Yakubutsu Seishin Kodo)
Vol. 5
Issue 1
Pg. 1-9
(May 1985)
ISSN: 0285-5313 [Print] Japan |
PMID | 2996254
(Publication Type: Journal Article)
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Chemical References |
- Vasopressins
- Thyrotropin-Releasing Hormone
- Adrenocorticotropic Hormone
- DN 1417
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Topics |
- Adrenocorticotropic Hormone
(therapeutic use)
- Amnesia
(drug therapy, etiology)
- Animals
- Hypoxia
(complications)
- Male
- Memory
(drug effects)
- Mice
- Thyrotropin-Releasing Hormone
(analogs & derivatives, therapeutic use)
- Vasopressins
(therapeutic use)
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