Suloctidil has been evaluated in the baboon for its antithrombotic efficacy using models of both acute and chronic arterial thrombogenesis. Acute
thrombus formation was initiated by
Dacron vascular grafts inserted as extension segments into chronic arteriovenous shunts. 111In-platelet deposition was measured by
scintillation camera imaging for one hour. The results after
oral administration of
suloctidil (100 mg/kg/d in two divided doses) were not different from control studies. Moreover, concurrent
heparin anticoagulation did not affect 111In-platelet deposition compared with control data. In contrast,
ticlopidine (20 mg/kg/d) significantly decreased platelet deposition that was reduced further by the addition of
heparin. Chronic arterial-
thromboembolism was initiated by segments of
polyurethane (
Biomer)
cannula introduced into chronic arteriovenous shunts.
Thrombus formation by the
polyurethane cannula was measured as 111In-platelet turnover (corrected for removal of senescent platelets).
Cannula platelet consumption was unaffected by
suloctidil (20 mg/kg/d given in two divided doses for two days preceding and throughout the period of platelet survival measurement). In contrast,
dipyridamole (10 mg/kg/d) and
sulfinpyrazone (100 mg/kg/d) completely interrupted
cannula platelet consumption. We conclude that
suloctidil probably has little or no effect on platelet-dependent
thrombus formation.