Added value of the DIC score and of D-dimer to predict outcome after successfully resuscitated out-of-hospital cardiac arrest.

Abstract

BACKGROUND:

Recent Korean data suggest a high prevalence of overt disseminated intravascular coagulation (DIC) and a good predictive performance of the ISTH DIC score in successfully resuscitated out-of-hospital cardiac arrest.

OBJECTIVES:

We hypothesised that in a European cohort of resuscitated out-of-hospital cardiac arrest patients the prevalence of DIC is substantially lower. Furthermore, the determination of D-dimer levels at admission, but not the DIC score, could improve mortality prediction above traditional predictors.

PATIENTS/METHODS:

Data were extracted from a prospective cardiac arrest registry including patients admitted between 2006 and 2015, who achieved return of spontaneous circulation and had parameters for DIC score calculation available. The primary outcome was the prevalence of overt DIC at admission. Secondary outcomes included the association of overt DIC with 30-day mortality and the contribution of the DIC score and D-dimer levels to 30-day mortality prediction using logistic regression. Three stepwise models were evaluated by receiver-operating-characteristic analysis.

RESULTS:

Out of 1179 patients 388 were included in the study. Overt DIC was present in 8% of patients and associated with substantial 30-day mortality (83% vs. 39%). The AUC for model 1, including traditional mortality predictors, was 0.83. The inclusion of D-dimer levels significantly improved prognostication above traditional predictors (model 3, AUC 0.89), whereas the inclusion of the DIC Score had no effect on mortality prediction (model 2, AUC 0.83).

CONCLUSION:

Overt DIC was rare in a European cohort of out-of-hospital cardiac arrest patients. D-dimer levels improved 30-day mortality prediction and provided added value to assess early mortality risk after successful resuscitation.

• Authors: N Buchtele, A Schober, C Schoergenhofer, A O Spiel, L Mauracher, C Weiser, F Sterz, B Jilma, M Schwameis
• Journal: European journal of internal medicine (Eur J Intern Med) Vol. 57 Pg. 44-48 (11 2018) ISSN: 1879-0828 [Electronic] Netherlands
• PMID: 29958747 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Chemical References

• Fibrin Fibrinogen Degradation Products
• fibrin fragment D

Topics

• Aged
• Austria (epidemiology)
• Disseminated Intravascular Coagulation (mortality)
• Female
• Fibrin Fibrinogen Degradation Products (analysis)
• Fibrinolysis
• Humans
• Kaplan-Meier Estimate
• Logistic Models
• Male
• Middle Aged
• Out-of-Hospital Cardiac Arrest (mortality, therapy)
• Prognosis
• Prospective Studies
• ROC Curve
• Resuscitation
• Severity of Illness Index
• Time Factors