[Electron-cytochemical study of microglia in Alzheimer's disease and senile dementia].

Abstract

Electron cytochemistry was employed to identify microglial cells by nucleoside diphosphatase (NDPase) in the senile plaques of the autopsy brain in Alzheimer's disease and senile dementia. It has been elucidated that processes of microglial cells enter a senile plaque and are closely connected with amyloid accumulation. A positive reaction to NDPase revealed in the extracellular substance suggests that these cells play an important role in the accumulation of amyloid in a senile plaque.

• Authors: V M Vostrikov
• Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 85 Issue 7 Pg. 974-6 ( 1985) ISSN: 0044-4588 [Print] Russia (Federation)
• Vernacular Title: Elektronno-tsitokhimicheskoe issledovanie mikroglii pri bolezni Al'tsgeĭmera i senil'noĭ dementsii.
• PMID: 2994329 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Amyloid
• Phosphoric Monoester Hydrolases
• Acid Anhydride Hydrolases
• nucleoside-diphosphatase

Topics

• Acid Anhydride Hydrolases
• Aged
• Alzheimer Disease (enzymology, pathology)
• Amyloid (metabolism)
• Brain (enzymology, pathology)
• Dementia (enzymology, pathology)
• Histocytochemistry
• Humans
• Microscopy, Electron
• Neuroglia (enzymology, pathology)
• Phosphoric Monoester Hydrolases (metabolism)