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HLA-DRw6 as a risk factor for active cytomegalovirus but not for herpes simplex virus infection after renal allograft transplantation.

Abstract
To study genetically determined susceptibility to cytomegalovirus and herpes simplex virus infections in patients given renal transplants a prospective study was performed of 68 consecutive patients receiving their first cadaveric kidney allograft. The recipients positive for HLA-DRw6 showed a significantly increased incidence of active cytomegalovirus infection as early as the 10th week after transplantation (p less than 0.05). No relation with other human leucocyte antigens was found, nor did a correlation exist between HLA typing and the incidence of herpes simplex virus infections. Furthermore, recipients positive for HLA-DRw6 with secondary cytomegalovirus infections excreted infectious virus more often (p less than 0.01) and showed more clinical symptoms (p less than 0.01) than a comparable group of recipients negative for HLA-DRw6. These observations may have practical implications for the treatment of patients who have had renal transplant operations.
AuthorsH W Roenhorst, A M Tegzess, J M Beelen, J M Middeldorp, T H The
JournalBritish medical journal (Clinical research ed.) (Br Med J (Clin Res Ed)) Vol. 291 Issue 6496 Pg. 619-22 (Sep 07 1985) ISSN: 0267-0623 [Print] England
PMID2992676 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • HLA Antigens
  • HLA-DR6 Antigen
  • Histocompatibility Antigens Class II
Topics
  • Adolescent
  • Adult
  • Aged
  • Cytomegalovirus Infections (immunology, microbiology)
  • Female
  • Graft Rejection
  • HLA Antigens (analysis)
  • HLA-DR6 Antigen
  • Herpes Simplex (immunology, microbiology)
  • Histocompatibility Antigens Class II (analysis)
  • Humans
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk
  • Time Factors

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