Abstract |
To study genetically determined susceptibility to cytomegalovirus and herpes simplex virus infections in patients given renal transplants a prospective study was performed of 68 consecutive patients receiving their first cadaveric kidney allograft. The recipients positive for HLA-DRw6 showed a significantly increased incidence of active cytomegalovirus infection as early as the 10th week after transplantation (p less than 0.05). No relation with other human leucocyte antigens was found, nor did a correlation exist between HLA typing and the incidence of herpes simplex virus infections. Furthermore, recipients positive for HLA-DRw6 with secondary cytomegalovirus infections excreted infectious virus more often (p less than 0.01) and showed more clinical symptoms (p less than 0.01) than a comparable group of recipients negative for HLA-DRw6. These observations may have practical implications for the treatment of patients who have had renal transplant operations.
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Authors | H W Roenhorst, A M Tegzess, J M Beelen, J M Middeldorp, T H The |
Journal | British medical journal (Clinical research ed.)
(Br Med J (Clin Res Ed))
Vol. 291
Issue 6496
Pg. 619-22
(Sep 07 1985)
ISSN: 0267-0623 [Print] England |
PMID | 2992676
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA Antigens
- HLA-DR6 Antigen
- Histocompatibility Antigens Class II
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Topics |
- Adolescent
- Adult
- Aged
- Cytomegalovirus Infections
(immunology, microbiology)
- Female
- Graft Rejection
- HLA Antigens
(analysis)
- HLA-DR6 Antigen
- Herpes Simplex
(immunology, microbiology)
- Histocompatibility Antigens Class II
(analysis)
- Humans
- Kidney Transplantation
- Male
- Middle Aged
- Prospective Studies
- Risk
- Time Factors
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