[Transmembrane potential and electrogenicity of thrombocyte Na, K-ATPase in different forms of hypertension in rats].

Abstract

The fluorescent dye 3,3'-dipropylthiadicarbocyanine iodide, dis-C3-(5), was used to study the membrane potential of platelets in rats with renal, DOCA-induced and spontaneous hypertension. The magnitude of the transmembrane potential in platelets combines the activity of electrogenic Na, K-ATPase and the rate of ion diffusion across the plasma membrane. The basal potential is 12 = 14 mB as lowered only in spontaneously hypertensive rats. The decrease of the basal potential is made for electrogenicity of platelet Na, K-ATPase in spontaneously hypertensive rats.

• Authors: G M Kravtsov, N A Postnova, Iu V Postnov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 100 Issue 8 Pg. 174-6 (Aug 1985) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Transmembrannyĭ potentsial i élektrogennost' Na, K-ATFazy trombotsitov pri razlichnykh formakh gipertenzii u krys.
• PMID: 2992629 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Desoxycorticosterone
• Ouabain
• Potassium Chloride
• Sodium-Potassium-Exchanging ATPase

Topics

• Animals
• Blood Platelets (drug effects, enzymology, physiology)
• Desoxycorticosterone (toxicity)
• Hypertension (chemically induced, physiopathology)
• Hypertension, Renal (physiopathology)
• Male
• Membrane Potentials (drug effects)
• Ouabain (pharmacology)
• Potassium Chloride (pharmacology)
• Rats
• Rats, Inbred SHR
• Rats, Inbred Strains
• Sodium-Potassium-Exchanging ATPase (physiology)
• Spectrometry, Fluorescence (methods)