Abstract |
The regional kinetics of intravenously injected L-methyl-11C-methionine (11C-L-methionine) in the brain was investigated by positron emission tomography (PET) in 14 patients with gliomas. In both tumor and unaffected brain the tracer uptake reached a nearly constant level in 5 min or less. The ratio between the uptake of 11C-L-methionine by high-grade tumors and the uptake by unaffected brain was 1.9-4.8. In two cases of low-grade astrocytoma the ratio was 0.8-1.0. High uptakes of 11C-L-methionine occurred in gliomas even in the absence of blood-brain barrier defects as observed by other methods. This indicates that besides active transport of amino acid, a larger extracellular space in tumor as compared with unaffected brain tissue may also contribute to the increased uptake of 11C-L-methionine--derived radioactivity. In some patients delineation of the tumors was improved by use of PET with 11C-L-methionine as compared with computed tomography, angiography, and, in some instances, PET with 68Ga-EDTA. PET with 11C-L-methionine permits better evaluation of the tumor extent and may affect preoperative grading.
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Authors | A Lilja, K Bergström, P Hartvig, B Spännare, C Halldin, H Lundqvist, B Långstrom |
Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
1985 Jul-Aug
Vol. 6
Issue 4
Pg. 505-14
ISSN: 0195-6108 [Print] United States |
PMID | 2992257
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Carbon Radioisotopes
- Gallium Radioisotopes
- Edetic Acid
- Methionine
- methionine methyl ester
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Topics |
- Adult
- Aged
- Astrocytoma
(diagnostic imaging)
- Brain Neoplasms
(diagnostic imaging)
- Carbon Radioisotopes
- Cerebral Angiography
- Edetic Acid
- Gallium Radioisotopes
- Glioblastoma
(diagnostic imaging)
- Glioma
(diagnostic imaging)
- Humans
- Male
- Methionine
(analogs & derivatives)
- Middle Aged
- Tomography, Emission-Computed
(methods)
- Tomography, X-Ray Computed
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