Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine.

Abstract

Drug, targeting ligand, and imaging agent are the three essential components in a nanoparticle-based drug delivery system. However, tremendous batch-to-batch variation of composition and drug content typically accompany the current approaches of building these components together. Herein, we report the design of photoactivatable platinum(IV) (Pt(IV)) amphiphiles containing one or two hydrophilic lactose targeting ligands per hydrophobic Pt(IV) prodrug for an all-in-one precise nanomedicine. Self-assembly of these Pt(IV) amphiphiles results in either micelle or vesicle formation with a fixed Pt/targeting moiety ratio and a constantly high content of Pt. The micelles and vesicles are capable of hepatoma cell-targeting, fluorescence/Pt-based CT imaging and have shown effective anticancer efficacy under laser irradiation in vitro and in vivo. This photoactivatable, active self-targeting, and multimodal theranostic amphiphile strategy shows great potential in constructing precise nanomedicine.

• Authors: Shasha He, Chan Li, Qingfei Zhang, Jianxun Ding, Xing-Jie Liang, Xuesi Chen, Haihua Xiao, Xiaoyuan Chen, Dongfang Zhou, Yubin Huang
• Journal: ACS nano (ACS Nano) Vol. 12 Issue 7 Pg. 7272-7281 (07 24 2018) ISSN: 1936-086X [Electronic] United States
• PMID: 29906087 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• Prodrugs
• Platinum

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Proliferation (drug effects)
• Drug Screening Assays, Antitumor
• Humans
• Liver Neoplasms, Experimental (diagnostic imaging, drug therapy)
• Male
• Mice
• Mice, Inbred Strains
• Multimodal Imaging
• Organoplatinum Compounds (chemical synthesis, chemistry, pharmacology)
• Platinum (chemistry, pharmacology)
• Prodrugs (chemical synthesis, chemistry, pharmacology)
• Theranostic Nanomedicine
• Tumor Cells, Cultured