Immediate laser-induced hemostasis in anticoagulated rats subjected to oral soft tissue surgery: a double-blind study.

Abstract

Given the growing trend towards medical indications for continuous use of anticoagulants, the number of patients on these medications continues to rise. The management of patients on oral anticoagulants requiring oral surgical procedures has aroused much controversy. Changes in an anticoagulation regimen are associated with an increased risk of thromboembolism. However, it seems logical and advantageous for the patients' health if surgery could be performed without any change to the anticoagulation therapy. In dentistry, high-power lasers have been poorly explored in this field. The hemostatic properties of high-power lasers could be helpful during oral soft tissue surgeries in anticoagulated patients. The aim of this study was to compare bleeding time in anticoagulated rats after lingual frenectomy performed with a scalpel or diode laser with bleeding time in healthy animals. Twenty-four male Wistar rats were assigned to four groups (n = 6): (CS) Control-Scalpel Surgery; (AS) Anticoagulated-Scalpel Surgery; (CL) Control-Laser (diode laser 810 nm/1.5 W) Surgery; and (AL) Anticoagulated-Laser Surgery (diode laser 810 nm/1.5 W). Warfarin administration was used to induce anticoagulation. Blood was blotted every 30 seconds with filter paper until bleeding stopped to verify bleeding time. Two blinded researchers performed the surgeries and collected the bleeding time data. Diode laser surgery led to complete hemostasis in rats during and after lingual frenectomy. Zero bleeding was assessed during surgeries and after diode laser surgeries in anticoagulated rats. Laser-induced hemostasis offered an alternative solution to the controversial issue of intraoperative and postoperative bleeding control in patients on anticoagulation therapy.

• Authors: Flavio Halak de Oliveira Campos, Lorraine Braga Ferreira, Marcelo Munhoes Romano, Maria Stella Moreira, Carlos de Paula Eduardo, Karen Müller Ramalho
• Journal: Brazilian oral research (Braz Oral Res) Vol. 32 Pg. e56 (Jun 07 2018) ISSN: 1807-3107 [Electronic] Brazil
• PMID: 29898023 (Publication Type: Comparative Study, Evaluation Study, Journal Article)

Chemical References

• Anticoagulants
• Warfarin

Topics

• Animals
• Anticoagulants (therapeutic use)
• Bleeding Time
• Blood Coagulation (radiation effects)
• Double-Blind Method
• Laser Coagulation (methods)
• Lasers, Semiconductor (therapeutic use)
• Lingual Frenum (surgery)
• Male
• Postoperative Hemorrhage (prevention & control)
• Rats, Wistar
• Reproducibility of Results
• Risk Factors
• Thromboembolism
• Treatment Outcome
• Warfarin (therapeutic use)