Neurotransplantation therapy.

Abstract

Neurotransplantation may be a promising approach for therapy of cerebellar diseases characterized by a substantial loss of neurons. Neurotransplantation could rescue neurons from degeneration and maintain cerebellar reserve, facilitate cerebellar compensation, or help reconstruct damaged neural circuits by cell substitution. These mechanisms of action can be of varying importance according to the type of cerebellar disease. Neurotransplantation therapy in cerebellar ataxias is still at the stage of experimental studies. There is currently little knowledge regarding cerebellar patients. Nevertheless, data provided by experiments in animal models of cerebellar degeneration and both clinical studies and experiences in patients with other neurologic diseases enable us to suggest basic principles, expectations, limitations, and future directions of neurotransplantation therapy for cerebellar diseases.

• Authors: Jan Cendelin, Hiroshi Mitoma
• Journal: Handbook of clinical neurology (Handb Clin Neurol) Vol. 155 Pg. 379-391 ( 2018) ISSN: 0072-9752 [Print] Netherlands
• PMID: 29891073 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Topics

• Animals
• Brain Tissue Transplantation (methods)
• Cerebellar Ataxia (surgery)
• Disease Models, Animal
• Humans