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Interferons inhibit syncytia-forming ability and in vitro transmission of human T-cell leukemia virus.

Abstract
Interferon(IFN)-alpha and -beta strongly inhibited syncytia formation of human T-cell leukemia virus (HTLV). They also inhibited transmission of HTLV to normal human fibroblasts. These phenomena suggest a physiological role of IFNs in defense against HTLV infection.
AuthorsJ Nishida, H Yoshikura, T Okabe, A Urabe, F Takaku
JournalJapanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 76 Issue 4 Pg. 249-52 (Apr 1985) ISSN: 0910-5050 [Print] Japan
PMID2989059 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Interferon Type I
  • Viral Proteins
  • Methionine
Topics
  • Animals
  • Cats
  • Deltaretrovirus (drug effects, metabolism)
  • Fibroblasts (microbiology)
  • Humans
  • Interferon Type I (pharmacology)
  • Leukemia (transmission)
  • Methionine (metabolism)
  • Tumor Virus Infections (transmission)
  • Viral Proteins (biosynthesis)

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