The Spontaneous Regression of Grade 3 Methotrexate-related Lymphomatoid Granulomatosis: A Case Report and Literature Review.

Abstract

Lymphomatoid granulomatosis (LYG) is a rare lung disorder diagnosed by radiological imaging of multiple pulmonary nodules and occasionally induced by methotrexate (MTX) use. To date, the treatment of LYG has not been standardized. We herein report the case of a patient with grade 3 MTX-related LYG who presented a bulky lung mass. Importantly, the disease condition only improved after the discontinuation of MTX and remained stable for more than 1 year. Chest physicians should be aware that LYG can develop as a single lung mass and spontaneously regress, even without aggressive chemotherapy, following the cessation of MTX.

• Authors: Naoto Aiko, Akimasa Sekine, Shigeaki Umeda, Takuma Katano, Goshi Matama, Kohsuke Isomoto, Ryota Otoshi, Takashi Ogura
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 57 Issue 21 Pg. 3163-3167 (Nov 01 2018) ISSN: 1349-7235 [Electronic] Japan
• PMID: 29877270 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antimetabolites, Antineoplastic
• Methotrexate

Topics

• Aged
• Antimetabolites, Antineoplastic (therapeutic use)
• Humans
• Lymphomatoid Granulomatosis (diagnostic imaging, drug therapy, pathology)
• Male
• Methotrexate (therapeutic use)
• Multiple Pulmonary Nodules (diagnostic imaging, drug therapy, pathology)
• Neoplasm Grading
• Radiography
• Remission, Spontaneous
• Withholding Treatment