Induction of tumors with cycasin in newborn and preweanling rats.

Abstract

Comprehensive studies of carcinogenesis in newborn or preweanling SD rats were conducted under various dose schedules of cycasin (CAS: 14901-08-7) administration. When cycasin was given sc to newborn rats at day 0, tumors were detected in more than 80% of rats of both sexes; kidney tumors were by far the most common. The incidences of tumors declined in the older groups, namely, over 60% in both sexes in the 7-day group, 55% in males and 8.3% in females in 14-day rats, and 0% in 21-day groups. By multiple administration, tumor incidences elevated considerably. Administration ip of cycasin also gave rise to tumor induction in newborn rats. A total of 435 kidney tumors found in the experiments were studied pathologically. Most of them were classified as mesenchymal tumor; some of them metastasized. A few other tumors were found in the liver and colon.

• Authors: R Fukunishi, A Kadota, A Yoshida, N Hirota
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 74 Issue 6 Pg. 1275-81 (Jun 1985) ISSN: 0027-8874 [Print] United States
• PMID: 2987594 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Azo Compounds
• Cycasin

Topics

• Adenocarcinoma (chemically induced, pathology)
• Animals
• Animals, Newborn
• Animals, Suckling
• Azo Compounds
• Carcinoma, Hepatocellular (chemically induced, pathology)
• Colonic Neoplasms (chemically induced, pathology)
• Cycasin
• Female
• Kidney Neoplasms (chemically induced, pathology)
• Liver Neoplasms (chemically induced, pathology)
• Male
• Mesenchymoma (chemically induced, pathology)
• Neoplasms, Experimental (chemically induced, pathology)
• Rats
• Rats, Inbred Strains