Chronic alpha-adrenoceptor blockade with trimazosin in congestive heart failure.

Abstract

We evaluated chronic adjunctive alpha-1 receptor blockade with trimazosin in congestive heart failure. This agent produced hemodynamic effects consistent with venodilation (reduced left ventricular volume and filling pressure with increased left ventricular ejection fraction), but only during exercise. Resting hemodynamic parameters and exercise duration were not significantly altered by chronic alpha-1 receptor blockade.

• Authors: P C Kirlin, S Das, B Pitt
• Journal: International journal of cardiology (Int J Cardiol) Vol. 8 Issue 1 Pg. 89-92 (May 1985) ISSN: 0167-5273 [Print] Netherlands
• PMID: 2987137 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Piperazines
• Receptors, Adrenergic, alpha
• Vasodilator Agents
• trimazosin

Topics

• Chronic Disease
• Exercise Test
• Heart Failure (drug therapy)
• Hemodynamics (drug effects)
• Humans
• Middle Aged
• Piperazines (therapeutic use)
• Receptors, Adrenergic, alpha (drug effects)
• Vasodilator Agents (therapeutic use)