Aurora B: A new promising therapeutic target in cancer.

Abstract

A critical step for maintenance of genetic stability is chromosome segregation, which requires a high coordination of cellular processes. Loss of mitotic regulation is a possible cause of aneuploidy in human epithelial malignancy and it is thought to create an abnormal nuclear morphology in cancer cells. Serine/threonine protein kinase Aurora B gene plays a regulatory role from G2 to cytokinesis, encompassing key cell cycle events such as centrosome duplication, chromosome bi-orientation, and segregation. The overexpression of Aurora B has been observed in several tumour types, and has been linked with a poor prognosis for cancer patients. Therapeutic inhibition of Aurora kinase showed great promise as a probable anticancer regime because of its important role during cell division.

• Authors: Paolo Chieffi
• Journal: Intractable & rare diseases research (Intractable Rare Dis Res) Vol. 7 Issue 2 Pg. 141-144 (May 2018) ISSN: 2186-3644 [Print] Japan
• PMID: 29862159 (Publication Type: Journal Article)