Abstract |
Fogelman's score (FS) was used to determine the usefulness of 99mTc pyrophosphate (Tc-PP) bone scintigraphy in the evaluation of dialysis osteodystrophy. FS correlated well with bone 47Ca accretion rate. It remained stable after six months in patients treated with 1 alpha ( OH)D3 and increased significantly in a randomised group of untreated patients. It decreased after two years of 1 alpha ( OH)D3 therapy while serum calcium increased and iPTH and alkaline phosphatases decreased. Patients with low FS, treated by 1 alpha ( OH)D3, rapidly developed hypercalcaemia. In cases of spontaneous hypercalcaemia, parathyroidectomy did not normalise serum calcium in patients with low FS despite a significant decrease in serum iPTH. Lower FS were associated with a higher increase in serum aluminium after desferrioxamine (DFO) administration and in two cases of proven aluminium osteomalacia, DFO therapy was followed by a dramatic increase in FS.
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Authors | J L Vanherweghem, A Schoutens, P Bergman, M Dhaene, M Goldman, M Fuss, P Kinnaert |
Journal | Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
(Proc Eur Dial Transplant Assoc Eur Ren Assoc)
Vol. 21
Pg. 431-4
( 1985)
England |
PMID | 2986102
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Diphosphates
- Technetium Tc 99m Pyrophosphate
- Technetium
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Topics |
- Bone and Bones
(diagnostic imaging)
- Chronic Kidney Disease-Mineral and Bone Disorder
(diagnostic imaging, etiology)
- Diphosphates
- Humans
- Radionuclide Imaging
- Renal Dialysis
(adverse effects)
- Technetium
- Technetium Tc 99m Pyrophosphate
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