Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone.

Abstract

Evidence from three types of experiments indicates that platelet activating factor (PAF)1 is an important mediator of endotoxin-induced hypotension in rats. a) Endotoxin infusion stimulates the time-dependent appearance of PAF in the blood. b) PAF infusion results immediately (less than 30 sec) in hypotension while endotoxin-induced hypotension takes 3-5 min to occur, allowing time for PAF production. c) Infusion of the specific PAF-receptor antagonist kadsurenone (2.2 mumole/kg bolus, 0.9 mumoles/min/kg continuous infusion), which inhibits PAF-induced hypotension by 67%, causes a 67% reversal of endotoxin-elicited hypotension. An additional finding of this study is that rats respond hypotensively to each of a series of low-dose PAF infusions but only to the first low-dose endotoxin infusion. These endotoxin-refractory rats do respond to subsequent PAF infusions.

• Authors: T W Doebber, M S Wu, J C Robbins, B M Choy, M N Chang, T Y Shen
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 127 Issue 3 Pg. 799-808 (Mar 29 1985) ISSN: 0006-291X [Print] United States
• PMID: 2985058 (Publication Type: Journal Article)

Chemical References

• Benzofurans
• Benzopyrans
• Endotoxins
• Lignans
• Platelet Activating Factor
• Platelet Membrane Glycoproteins
• Receptors, Cell Surface
• Receptors, G-Protein-Coupled
• platelet activating factor receptor
• kadsurenone

Topics

• Animals
• Benzofurans
• Benzopyrans (pharmacology)
• Endotoxins
• Escherichia coli
• Female
• Hypotension (chemically induced)
• Kinetics
• Lignans
• Platelet Activating Factor (physiology)
• Platelet Membrane Glycoproteins
• Rats
• Rats, Inbred Strains
• Receptors, Cell Surface (drug effects, physiology)
• Receptors, G-Protein-Coupled