Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease.

Abstract

OBJECTIVE:

Blood lipids are well-known risk factors for coronary heart disease (CHD). The aim of this study was to explore the association between 17 lipid-related gene polymorphisms and CHD.

METHODS:

The current study examined with 784 CHD cases and 739 non-CHD controls. Genotyping was performed on the MassARRAY iPLEX® assay platform.

RESULTS:

Our analyses revealed a significant association of APOE rs7259620 with CHD (genotype: χ2=6.353, df=2, p=0.042; allele: χ2=5.05, df=1, p=0.025; recessive model: χ2=5.57, df=1, p=0.018). A further gender-based subgroup analysis revealed significant associations of APOE rs7259620 and PPAP2B rs72664392 with CHD in males (genotype: χ2=8.379, df=2, p=0.015; allele: χ2=5.190, df=1, p=0.023; recessive model: χ2=19.3, df=1, p<0.0001) and females (genotype: χ2=9.878, df=2, p=0.007), respectively. Subsequent breakdown analysis by age showed that CETP rs4783961, MLXIPL rs35493868, and PON2 rs12704796 were significantly associated with CHD among individuals younger than 55 years of age (CETP rs4783961: χ2=8.966, df=1, p=0.011 by genotype; MLXIPL rs35493868: χ2=4.87, df=1, p=0.027 by allele; χ2=4.88, df=1, p=0.027 by dominant model; PON2 rs12704796: χ2=6.511, df=2, p=0.039 by genotype; χ2=6.210, df=1, p=0.013 by allele; χ2=5.03, df=1, p=0.025 by dominant model). Significant allelic association was observed between LEPR rs656451 and CHD among individuals older than 65 years of age (χ2=4.410, df=1, p=0.036).

CONCLUSION:

Our study revealed significant associations of APOE, PPAP2B, CETP, MLXIPL, PON2, and LEPR gene polymorphisms with CHD among the Han Chinese.

• Authors: Nan Wu, Guili Liu, Yi Huang, Qi Liao, Liyuan Han, Huandan Ye, Shiwei Duan, Xiaomin Chen
• Journal: Anatolian journal of cardiology (Anatol J Cardiol) Vol. 19 Issue 6 Pg. 360-367 (Jun 2018) ISSN: 2149-2271 [Electronic] Turkey
• PMID: 29848931 (Publication Type: Journal Article)

Chemical References

• Adipokines
• Aryldialkylphosphatase
• PON2 protein, human

Topics

• Adipokines (genetics, metabolism)
• Age Factors
• Aged
• Aryldialkylphosphatase (genetics)
• Asian People (genetics)
• Case-Control Studies
• China
• Coronary Disease (genetics)
• Female
• Genetic Predisposition to Disease
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Risk Factors
• Sex Factors
• Signal Transduction (genetics)