HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pantoyl-gamma-aminobutyric acid facilitates cholinergic function in the central nervous system.

Abstract
Pantoyl-gamma-aminobutyric acid (P-GABA) administered i.p. inhibited scopolamine- and atropine-induced locomotor activities in mice, but did not inhibit methamphetamine- and apomorphine-induced locomotor activities. In radiolabeled ligand binding experiments, P-GABA did not inhibit the bindings of [3H]quinuclidinyl benzilate, [3H]spiroperidol and [3H]apomorphine to rat brain membranes, but inhibited that of [3H]muscimol. GABA and P-GABA enhanced K+ (25 mM)-induced release of [3H]acetylcholine from slices of the cerebral cortex and hippocampus dose-dependently, and their effects were antagonized by bicuculline but not by tetrodotoxin. These results suggest that P-GABA binds to GABA receptors causing enhanced cholinergic neurotransmission in the central nervous system. The results are discussed in relation to the clinical use of P-GABA in treatment of Alzheimer's disease and senile dementia of the Alzheimer type.
AuthorsM Nakahiro, N Fujita, I Fukuchi, K Saito, T Nishimura, H Yoshida
JournalThe Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther) Vol. 232 Issue 2 Pg. 501-6 (Feb 1985) ISSN: 0022-3565 [Print] United States
PMID2982013 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, GABA-A
  • pantogab
  • Pantothenic Acid
  • gamma-Aminobutyric Acid
  • Acetylcholine
Topics
  • Acetylcholine (metabolism)
  • Animals
  • Brain (drug effects, metabolism)
  • Female
  • Male
  • Mice
  • Mice, Inbred ICR
  • Motor Activity (drug effects)
  • Pantothenic Acid (analogs & derivatives, pharmacology)
  • Parasympathetic Nervous System (drug effects)
  • Rats
  • Rats, Inbred Strains
  • Receptors, GABA-A (drug effects)
  • Synaptic Transmission (drug effects)
  • gamma-Aminobutyric Acid (analogs & derivatives, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: