[Content of phospholipid, cerebroside and cerebroside sulfate in the central nervous system of mice with acute experimental viral demyelination].

Abstract

A study was made of the content of phospholipids, cerebrosides and cerebroside sulfates in the central nervous system of mice with experimental acute viral encephalomyelitis. No considerable changes in phospholipid content were revealed. A significant drop in the content of cerebrosides and cerebroside sulfates was defected in the CNS, being more pronounced in the spinal cord of sick animals. The reduction in the content of glycolipids can be explained by myelin disintegration and by the effect of viruses on the olygodendrocytes in which cerebrosides and cerebroside sulfates are synthesized.

• Authors: Kh N Annanepesov, M V Levitina, E V Sergienko
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 99 Issue 1 Pg. 33-4 (Jan 1985) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Soderzhanie fosfolipidov, tserebrozidov i tserebrozid-sulfatov v tsentral'noĭ nervnoĭ sisteme mysheĭ pri ostroĭ virusnoĭ éksperimental'noĭ demielinizatsii.
• PMID: 2981576 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Cerebrosides
• Phospholipids

Topics

• Acute Disease
• Animals
• Brain Chemistry
• Cerebrosides (analysis)
• Chromatography, Thin Layer
• Demyelinating Diseases (metabolism)
• Hepatitis, Viral, Animal (metabolism)
• Murine hepatitis virus
• Phospholipids (analysis)
• Rats
• Spinal Cord (analysis)