Abstract |
Immunoglobulin G ( IgG) and IgM antibodies to human T-cell leukemia/lymphoma virus-I (HTLV-I)-associated membrane antigens (HTLV-I-MA) were assayed by indirect cytospin immunofluorescence, and IgG and IgM antibodies to purified HTLV-I were assayed by enzyme-linked immunosorbent assay in sera from 119 immunologically well-characterized promiscuous male homosexuals in The Netherlands, of whom 9 suffered from acquired immune deficiency syndrome ( AIDS), 18 suffered from lymphadenopathy syndrome (LAS), and 5 suffered from gay bowel syndrome. Antibodies to HTLV-I-MA were present in four of nine AIDS patients, including one patient with antibodies to purified HTLV-I. Antibodies to HTLV-I-MA were present in 6 of 18 LAS patients, including 3 patients with antibodies to purified HTLV-I. Of five patients with gay bowel syndrome, one had IgG and IgM antibodies to HTLV-I-MA. Of the four HTLV-I seropositive AIDS patients, two had IgG and IgM antibodies to HTLV-I or HTLV-I-MA, one had only IgG antibodies, and one had only IgM antibodies. Of the six HTLV-I seropositive LAS patients, four had IgG and IgM antibodies to HTLV-I or HTLV-I-MA, and two had only IgM antibodies. In the sera from 27 healthy homosexuals with and 60 without T-cell subset imbalances, no antibodies to HTLV-I or HTLV-I-MA were detected.
|
Authors | J Goudsmit, F Miedema, R J Wijngaarden-du Bois, M T Roos, P T Schellekens, R A Coutinho, J van der Noordaa, C J Melief |
Journal | Journal of virology
(J Virol)
Vol. 53
Issue 1
Pg. 287-91
(Jan 1985)
ISSN: 0022-538X [Print] United States |
PMID | 2981348
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antibodies
- Antigens, Viral
- HIV Antigens
- Immunoglobulin G
- Immunoglobulin M
|
Topics |
- Acquired Immunodeficiency Syndrome
(immunology, microbiology)
- Antibodies
- Antigens, Viral
(analysis, immunology)
- Deltaretrovirus
(immunology)
- Diarrhea
(immunology, microbiology)
- Enzyme-Linked Immunosorbent Assay
- Fluorescent Antibody Technique
- HIV Antigens
- Homosexuality
- Humans
- Immunoglobulin G
- Immunoglobulin M
- Immunologic Deficiency Syndromes
(immunology, microbiology)
- Male
- T-Lymphocytes, Helper-Inducer
(immunology)
- T-Lymphocytes, Regulatory
(immunology)
|