Mild
hypothermia combined with minimally invasive
hematoma evacuation was evaluated in the treatment of
hypertensive intracerebral hemorrhage to reduce inflammatory response of brain tissue around
hematoma and ameliorate brain function, and to investigate its safety, effectiveness and feasibility. A total of 206 patients with acute spontaneous
hypertensive intracerebral hemorrhage were collected clinically and randomly divided into minimally invasive
hematoma evacuation group (group A) and mild
hypothermia combined with minimally invasive
hematoma evacuation (group B). The National Institutes of Health
Stroke Scale (NIHSS) score was used before and
after treatment. Group A was treated with minimally invasive intracranial
hematoma evacuation using intracranial
hematoma grinding
puncture needle while group B received whole body water circulation type cooling blanket plus local cerebral mild
hypothermia therapy with
ice cap on the basis of
minimally invasive surgery. Patients brain tissue fragments around
hematoma taken out with rinsing during operation and at postoperative 1, 3 and 7 days were investigated. The contents of
tumor necrosis factor-α (TNF-α) in serum at postoperative 1, 3 and 7 days were evaluated by
enzyme-linked
immunosorbent assay (ELISA). For the degree of nerve function defect of patients in the two groups, NIHSS score was lower in group B than that in group A at days 3 and 7, and the differences were statistically significant (P<0.05). The serum TNF-α content and expression of nuclear factor-κB (NF-κB) in brain tissue around
hematoma reached the peak on the 3rd day. The TNF-α content and NF-κB expression were lower in group B than those in group A at each time-point (P<0.05). Mild
hypothermia combined with minimally invasive
hematoma evacuation can reduce the damage of
hematoma to the surrounding brain tissue, effectively alleviate inflammatory response and decrease brain tissue injury, thus ameliorating brain function.