Abstract | PURPOSE: DESIGN: Retrospective observational study, clinical case series SUBJECTS AND METHODS: We reviewed the medical charts of 15 eyes of 9 consecutive patients with ON in NMOSD who underwent apheresis between March 2010 and September 2017. All patients were seropositive for anti- aquaporin 4 (AQP4) antibody and resistant to steroid pulse therapy. Apheresis was performed by either simple plasma exchange or/and immune adsorption therapy. RESULTS: Twelve eyes (80%) showed improvement with logMAR > 0.3 at 1 month after apheresis. Within 1 month after apheresis therapy, logMAR on average significantly decreased, the magnitude of change being greatest within the first week. Thereafter visual acuity became stable in 10 of the 11 eyes, until 12 months. However, two eyes (12%) showed recurrence of visual acuity reduction 3 months after the cessation of apheresis. There were a few serious complications during and after apheresis, but these were completely treatable. CONCLUSIONS:
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Authors | Sotaro Mori, Takuji Kurimoto, Kaori Ueda, Makoto Nakamura |
Journal | Japanese journal of ophthalmology
(Jpn J Ophthalmol)
Vol. 62
Issue 4
Pg. 525-530
(Jul 2018)
ISSN: 1613-2246 [Electronic] Japan |
PMID | 29802557
(Publication Type: Journal Article, Observational Study)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Blood Component Removal
(methods)
- Child
- Drug Resistance
- Female
- Follow-Up Studies
- Glucocorticoids
(pharmacology)
- Humans
- Male
- Middle Aged
- Neuromyelitis Optica
(complications, diagnosis, therapy)
- Optic Neuritis
(diagnosis, etiology, therapy)
- Retrospective Studies
- Time Factors
- Treatment Outcome
- Visual Acuity
- Young Adult
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