Abstract |
Ninety-five patients with healed gastric ulcers were treated with ranitidine 150 mg at night plus either Caved-S two tablets twice daily, or an identical placebo preparation. Treatment was continued for 2 years: the recurrence rate after 1 year was 12.5% for single therapy and 19% for combined therapy, and 30 and 40% respectively after 2 years (differences not significant). No serious side-effects were encountered, but patients found the combination therapy difficult to take, and it conferred no clinical advantage. In a 3 month follow-up after stopping maintenance therapy, 11% of the patients had a symptomatic ulcer recurrence. It is therefore recommended that elderly patients with gastric ulceration should remain on maintenance therapy for life.
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Authors | A G Morgan, C Pacsoo, P Taylor, W A McAdam |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 1
Issue 6
Pg. 633-8
(Dec 1987)
ISSN: 0269-2813 [Print] England |
PMID | 2979691
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Drug Combinations
- Plant Extracts
- aluminum hydroxide, bismuth subnitrate, deglycyrrhizinised liquorice, magnesium carbonate, sodium bicarbonate drug combination
- Aluminum Hydroxide
- Ranitidine
- Sodium Bicarbonate
- Magnesium Hydroxide
- Bismuth
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Topics |
- Adult
- Aluminum Hydroxide
(administration & dosage)
- Anti-Ulcer Agents
(administration & dosage)
- Bismuth
(administration & dosage)
- Double-Blind Method
- Drug Combinations
- Drug Therapy, Combination
- Female
- Glycyrrhiza
- Humans
- Magnesium Hydroxide
- Male
- Middle Aged
- Plant Extracts
(administration & dosage)
- Ranitidine
(administration & dosage)
- Recurrence
- Sodium Bicarbonate
- Stomach Ulcer
(prevention & control)
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