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Does Caved-S decrease the gastric ulcer relapse rate during maintenance treatment with ranitidine?

Abstract
Ninety-five patients with healed gastric ulcers were treated with ranitidine 150 mg at night plus either Caved-S two tablets twice daily, or an identical placebo preparation. Treatment was continued for 2 years: the recurrence rate after 1 year was 12.5% for single therapy and 19% for combined therapy, and 30 and 40% respectively after 2 years (differences not significant). No serious side-effects were encountered, but patients found the combination therapy difficult to take, and it conferred no clinical advantage. In a 3 month follow-up after stopping maintenance therapy, 11% of the patients had a symptomatic ulcer recurrence. It is therefore recommended that elderly patients with gastric ulceration should remain on maintenance therapy for life.
AuthorsA G Morgan, C Pacsoo, P Taylor, W A McAdam
JournalAlimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 1 Issue 6 Pg. 633-8 (Dec 1987) ISSN: 0269-2813 [Print] England
PMID2979691 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • Drug Combinations
  • Plant Extracts
  • aluminum hydroxide, bismuth subnitrate, deglycyrrhizinised liquorice, magnesium carbonate, sodium bicarbonate drug combination
  • Aluminum Hydroxide
  • Ranitidine
  • Sodium Bicarbonate
  • Magnesium Hydroxide
  • Bismuth
Topics
  • Adult
  • Aluminum Hydroxide (administration & dosage)
  • Anti-Ulcer Agents (administration & dosage)
  • Bismuth (administration & dosage)
  • Double-Blind Method
  • Drug Combinations
  • Drug Therapy, Combination
  • Female
  • Glycyrrhiza
  • Humans
  • Magnesium Hydroxide
  • Male
  • Middle Aged
  • Plant Extracts (administration & dosage)
  • Ranitidine (administration & dosage)
  • Recurrence
  • Sodium Bicarbonate
  • Stomach Ulcer (prevention & control)

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