[ANTIARRHYTHMIC EFFECTS OF 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE HEMISUCCINATE IN COMPARISON TO MEXIDOL.]

Abstract

Based on the results of experiments on nonlinear white awake male rats it is established that 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate and mexidol exhibit a pronounced antiarrhythmic (antifibrillatory) activity on the calcium chloride arrhythmia model. The maximum effect was observed for hemisuccinate 2-ethyl-6-methyl-3-hydroxypyridine. This substaned; unlike mexidol, also showed high activity on the model of aconitine arrhythmia, which is typical of class I antiarrhytmics. Mexidol did not show this activity. Consequently, 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate possesses a wider therapeutic spectrum than the well-known antiarrhythmic drugs of class I (lidocaine, procainamide) and is comparable in this respect with class IV drug verapamil.

• Authors: A I Turilova, T S Gan'shina, N I Avdyunina, B M Pyatin, R S Mirzoyan
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 79 Issue 7 Pg. 8-11 ( 2016) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 29782738 (Publication Type: Comparative Study, Journal Article)

Chemical References

• 2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate
• Anti-Arrhythmia Agents
• Picolines
• Pyridines
• emoxypine succinate
• Calcium Chloride

Topics

• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Arrhythmias, Cardiac (chemically induced, drug therapy, physiopathology)
• Calcium Chloride (adverse effects, pharmacology)
• Disease Models, Animal
• Male
• Picolines (pharmacology)
• Pyridines (pharmacology)
• Rats