BMY-25801, an antiemetic agent free of D2-dopamine receptor antagonist properties.

Abstract

BMY-25801, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]2-(1-methyl-2-oxopropoxy ) benzamide, a new antiemetic agent free of D2-dopamine receptor antagonist properties, was effective against emesis induced by cytostatic agents (cisplatin, cyclophosphamide and doxorubicin) and total body radiation in the ferret. It also was effective against cisplatin-induced emesis in the dog; however, it was inactive against emesis caused by apomorphine and hydergine in the same species. In terms of activity profile, BMY-25801 could be differentiated both from metoclopramide and domperidone. Metoclopramide was nonselectively active against emesis induced by cytostatic agents, radiation and D2-dopamine receptor agonists, whereas domperidone was selectively effective against emesis induced by apomorphine and hydergine only. BMY-25801 failed to reveal any D2-dopamine receptor antagonist properties in several pharmacological tests (catalepsy, apomorphine stereotypy, serum prolactin, striatal dihydroxyphenylacetic acid and [3H]spiperone displacement) whereas metoclopramide was uniformly active in these tests. The activity profile of domperidone was compatible with its classification as a peripherally acting D2-dopamine receptor antagonist. BMY-25801 and metoclopramide antagonized serotonin-induced bradycardia (Bezold-Jarisch reflex) in the anesthetized rat, a response involving peripheral neuronal 5-HT3 receptors. Thus, BMY-25801 represents a novel antiemetic acting independently of D2-dopamine receptor mechanisms; however, its exact mode of action remains unknown.

• Authors: J A Gylys, R N Wright, W D Nicolosi, J P Buyniski, R R Crenshaw
• Journal: The Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther) Vol. 244 Issue 3 Pg. 830-7 (Mar 1988) ISSN: 0022-3565 [Print] United States
• PMID: 2978041 (Publication Type: Journal Article)

Chemical References

• Antiemetics
• Receptors, Dopamine
• Receptors, Dopamine D2
• Receptors, Serotonin
• batanopride
• Doxorubicin
• Cyclophosphamide
• Metoclopramide
• Apomorphine
• Cisplatin

Topics

• Animals
• Antiemetics (pharmacology)
• Apomorphine (antagonists & inhibitors)
• Cisplatin (antagonists & inhibitors)
• Cyclophosphamide (antagonists & inhibitors)
• Dogs
• Doxorubicin (antagonists & inhibitors)
• Female
• Ferrets
• Male
• Metoclopramide (analogs & derivatives, pharmacology)
• Receptors, Dopamine (drug effects)
• Receptors, Dopamine D2
• Receptors, Serotonin (drug effects)
• Reflex (drug effects)
• Vomiting (etiology, prevention & control)