The value of 18F-FDG PET/CT in patient with neurofibromatosis type 1: A case report and literature review.

Abstract

RATIONALE:

Neurofibromatosis type one (NF1) is characterized by cutaneous and nervous lesions, and the tendency to form plexiform neurofibromas (PNFs). PNFs may undergo malignant transformation into a malignant peripheral nerve sheath tumors (MPNSTs). MPNSTs often carry an significant morbidity and mortality.

PATIENT CONCERNS:

A 17-year-old man with gradually increased multiple subcutaneous soft lesions. He also presented with numerous lentigines and multiple café-au-lait macules on his body.

DIAGNOSES:

These were collagen neurofibroma, which were definitively diagnosed by pathology. NF1 was eventually diagnosed.

INTERVENTIONS:

These lesions were abnormal uptake of radiotracer, when he underwent positron emission tomography (PET) with fluorine-18-fluorodeoxyglucose (FDG) scanning. Standard uptake value (SUV) and other parameters can help to distinguish benign and malignant lesions in patient with NF1. He was underwent serials F-FDG PET/CT examinations to followed up, in order to monitor these lesions malignant transformation.

OUTCOMES:

So far, these subcutaneous soft lesions were not malignant transformation.

LESSONS:

F-FDG PET/CT is being increasingly used as an imaging modality to discover the systemic lesions and to discriminate between benign and malignant plexiform neurofibromas.

• Authors: Jiazhong Ren, Guoren Yang, Jing Zhou, Zheng Fu
• Journal: Medicine (Medicine (Baltimore)) Vol. 97 Issue 20 Pg. e10648 (May 2018) ISSN: 1536-5964 [Electronic] United States
• PMID: 29768331 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Fluorodeoxyglucose F18

Topics

• Adolescent
• Diagnosis, Differential
• Fluorodeoxyglucose F18 (administration & dosage)
• Humans
• Male
• Neurofibromatosis 1 (diagnostic imaging)
• Positron Emission Tomography Computed Tomography (methods)