Endothelial cell loss and graft survival after penetrating keratoplasty for laser iridotomy-induced bullous keratopathy.

Abstract

PURPOSE:

To assess corneal endothelial cell loss after penetrating keratoplasty (PK) treatment for laser iridotomy (LI)-induced bullous keratopathy (BK).

METHODS:

A retrospective study conducted on consecutive patients who underwent PK between March 2000 and December 2011. Patients who had undergone more than 24 months of follow-up were included. Patients who underwent PK were subcategorized into two groups based on their diagnosis of BK prior to PK; PK was performed to treat either LI-BK or non LI-BK. The cell density of the central corneal endothelium and the graft survival were evaluated during follow-up.

RESULTS:

Corneal endothelial cell density decreased in a similar fashion in both the LI-BK and non LI-BK patients, though the cell density decreased significantly faster in the LI-BK group than in the non LI-BK group throughout the 108 months of the study (p = 0.026). The mean cell loss at 36 months for the LI-BK group was 57.7% vs. 63.2% for the non LI-BK, 76.9% vs. 70.1% at 72 months, and 85.6% vs. 72.0% at 108 months. No eye among 21 eyes in the LI-BK group (0%) had failed grafts, whereas 4 of 25 eyes in the non LI-BK group (16.0%) had failed grafts at 60 months (p = 0.114).

CONCLUSIONS:

The outcome of PK for BK secondary to LI was no worse than the outcome of PK for other types of BK. However, our long-term follow-up after PK showed that cell density decreased faster in the LI-BK group than in the non LI-BK, suggesting that cell loss might be involved in the existence of LI prior to PK.

• Authors: Naoki Okumura, Ayaka Kusakabe, Noriko Koizumi, Koichi Wakimasu, Kanae Kayukawa, Masami Kondo, Kazuhiko Mori, Chie Sotozono, Shigeru Kinoshita
• Journal: Japanese journal of ophthalmology (Jpn J Ophthalmol) Vol. 62 Issue 4 Pg. 438-442 (Jul 2018) ISSN: 1613-2246 [Electronic] Japan
• PMID: 29766356 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Cell Count
• Corneal Diseases (etiology, surgery)
• Corneal Endothelial Cell Loss (etiology)
• Endothelium, Corneal (pathology)
• Female
• Follow-Up Studies
• Graft Survival
• Humans
• Iris (surgery)
• Keratoplasty, Penetrating (adverse effects)
• Laser Therapy (adverse effects)
• Male
• Middle Aged
• Retrospective Studies
• Visual Acuity
• Young Adult