A kinetic analysis of platelet monoamine oxidase activity in patients with panic attacks.

A kinetic analysis of platelet monoamine oxidase (MAO) was performed in 22 patients with panic disorder and 14 normal controls, using tyramine as a substrate. Patients and controls did not differ significantly for either Km or Vmax, when same sex contrasts were carried out. The results do not support some studies that have shown elevated MAO activity in patients with panic attacks. The reasons for the discrepancies between previous studies and the present one are explored.
AuthorsT R Norman, A Acevedo, I M McIntyre, F K Judd, G D Burrows
JournalJournal of affective disorders (J Affect Disord) 1988 Sep-Oct Vol. 15 Issue 2 Pg. 127-30 ISSN: 0165-0327 [Print] NETHERLANDS
PMID2975682 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Monoamine Oxidase
  • Adult
  • Aged
  • Agoraphobia (enzymology, psychology)
  • Fear (physiology)
  • Female
  • Humans
  • Kinetics
  • Male
  • Middle Aged
  • Monoamine Oxidase (blood)
  • Panic (physiology)
  • Phobic Disorders (enzymology)

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