[Comparative effectiveness of the combined use of fenazepam, haloperidol, lithium and metabolic preparations in treating the psychopathologic disorders with obsessions in slowly progressive schizophrenia].

Abstract	The effectiveness of combined phenazepam, lithium, haloperidol and metabolic drugs (alpha-tocopherol, pyridoxal phosphate, nicotinamide) treatment of patients with slow progredient schizophrenia is analyzed. The psychotropic drugs were administered at doses lower below mean therapeutic ones by 1/2 to 1/3. Combined therapy proved effective even in the cases resistant to active antipsychotic treatment. No considerable untoward effects (extrapyramidal disorders) were found. The therapy had a differentiated impact on the obsessive syndrome and other borderline psychopathologic states. These advantages allow one to recommend the therapy for long-term support in schizophrenic patients with benign course of the disease.
Authors	N M Kadysheva, A N Mokhovikov, K V Mosketi, G N Kryzhanovskiĭ
Journal	Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 88 Issue 10 Pg. 88-92 ( 1988) ISSN: 0044-4588 [Print] Russia (Federation)
Vernacular Title	Sravnitel'naia éffektivnost' kompleksnogo primeneniia fenazepama, galoperidola, litiia i metabolicheskikh preparatov v lechenii psikhopatologicheskikh rasstroĭstv s naviazchivostiami pri maloprogredientnoĭ shizofrenii.
PMID	2975124 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anti-Anxiety Agents Benzodiazepinones Benzodiazepines Vitamin E Niacinamide phenazepam Pyridoxal Phosphate Lithium alpha-Tocopherol Haloperidol Tocopherols
Topics	Adolescent Adult Aged Anti-Anxiety Agents Benzodiazepines Benzodiazepinones (therapeutic use) Chronic Disease Compulsive Personality Disorder (drug therapy, etiology) Drug Evaluation Drug Therapy, Combination Female Haloperidol (therapeutic use) Humans Lithium (therapeutic use) Male Middle Aged Niacinamide (therapeutic use) Personality Disorders (drug therapy) Psychopathology Pyridoxal Phosphate (therapeutic use) Schizophrenia (complications, drug therapy) Tocopherols Vitamin E (analogs & derivatives, therapeutic use) alpha-Tocopherol (analogs & derivatives)

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