Subacute effects of propranolol and B 24/76 on isoproterenol-induced rat heart hypertrophy in correlation with blood pressure.

Abstract

We compared the potential beta-receptor blocker, B 24/76 i.e. 1-(2,4-dichlorophenoxy)-3[2-3,4-dimethoxyphenyl)ethanolamino]-prop an-2-ol, which is characterized by beta 1-adrenoceptor blocking and beta 2-adrenoceptor stimulating properties with propranolol. The studies were performed using an experimental model of isoproterenol-induced heart hypertrophy in rats. A correlation of the blood pressure was neither found in the development nor in the attempt to suppress the development of heart hypertrophy with the two beta-receptor blockers. Both beta-blockers influenced the development of hypertrophy to a different, but not reproducible extent. It was possible to suppress the increased ornithine decarboxylase activity with both beta-blockers in hypertrophied hearts, but there was no effect on the heart mass. Neither propranolol nor B 24/76 could stop the changes in the characteristic myosin isoenzyme pattern of the hypertrophied rat heart. Thus, the investigations did not provide any evidence that the beta-receptor blockers propranolol and B 24/76 have the potency to prevent isoproterenol from producing heart hypertrophy.

• Authors: A Grisk, U Hoffmann, K U Möritz
• Journal: Biomedica biochimica acta (Biomed Biochim Acta) Vol. 47 Issue 7 Pg. 681-8 ( 1988) ISSN: 0232-766X [Print] Germany
• PMID: 2974281 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Isoenzymes
• Propranolol
• Myosins
• Ornithine Decarboxylase
• Isoproterenol

Topics

• Animals
• Blood Pressure (drug effects)
• Cardiomegaly (chemically induced, drug therapy)
• Isoenzymes (metabolism)
• Isoproterenol (toxicity)
• Myosins (metabolism)
• Ornithine Decarboxylase (metabolism)
• Propranolol (pharmacology)
• Rats
• Rats, Inbred Strains