[Implication of lipid peroxidation in triethyltin poisoning in the rat].

Abstract

Triethyltin intoxication induces, in vivo, a significant increase of malondialdehyde concentration in rat brain. After treatment with a Ginkgo biloba extract, an extract known to possess antiedematous and radical scavenging properties, the malondialdehyde level in the brain is significantly decreased. This suggests that a lipid peroxidation process is associated with cerebral oedema induced by triethyltin.

• Authors: R Boulieu, J F Munoz, O Macovschi, H Pacheco
• Journal: Comptes rendus des seances de la Societe de biologie et de ses filiales (C R Seances Soc Biol Fil) Vol. 182 Issue 2 Pg. 196-201 ( 1988) ISSN: 0037-9026 [Print] France
• Vernacular Title: Implication de la peroxydation lipidique dans l'intoxication par le triéthylétain chez le rat.
• PMID: 2973827 (Publication Type: English Abstract, Journal Article)

Chemical References

• Plant Extracts
• Trialkyltin Compounds
• Triethyltin Compounds
• Malondialdehyde

Topics

• Animals
• Brain Chemistry (drug effects)
• Brain Edema (chemically induced, drug therapy)
• Liver (analysis)
• Male
• Malondialdehyde (analysis, blood)
• Plant Extracts (therapeutic use)
• Rats
• Rats, Inbred Strains
• Trialkyltin Compounds (toxicity)
• Triethyltin Compounds (toxicity)