Abstract |
Studies on Albino Swiss mice and Wistar rats have demonstrated that tryptamide is less ulcerogenic than phenylbutazone, and markedly inhibits intestinal peristalsis. Both compounds have a similar tendency to accumulate in the body. Tryptamide produces a smaller hypotension and stimulates the respiratory amplitude to a lesser extent than phenylbutazone in a vivisectional experiment. Studies on the subacute and chronic toxicity have demonstrated that tryptamide administered orally (po) and intraperitioneally (ip) for 3 weeks, and orally for 3 months neither affects the body weight gain or the mass of internal organs, nor changes the locomotor activity; only in rats it disturbs the motor coordination. After ip administration tryptamide shows a moderate depressant effect on the bone marrow, evidenced by a decline in the blood hemoglobin content and the number of erythrocytes and blood platelets. As those changes were more pronounced after a 3-week than a 3-month administration, the observed effects are apparently reversible.
|
Authors | Z Kleinrok, M Sieklucka, G Rajtar, S J Czuczwar |
Journal | Polish journal of pharmacology and pharmacy
(Pol J Pharmacol Pharm)
1987 Nov-Dec
Vol. 39
Issue 6
Pg. 737-47
ISSN: 0301-0244 [Print] Poland |
PMID | 2972999
(Publication Type: Journal Article)
|
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Tryptamines
- Niacinamide
- tryptamide
- Transaminases
|
Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology, toxicity)
- Blood Pressure
(drug effects)
- Body Weight
(drug effects)
- Electrocardiography
- Female
- Gastric Mucosa
(drug effects)
- Intestines
(drug effects, physiology)
- Lethal Dose 50
- Locomotion
(drug effects)
- Male
- Mice
- Mice, Inbred Strains
- Motor Activity
(drug effects)
- Niacinamide
(analogs & derivatives, pharmacology, toxicity)
- Organ Size
(drug effects)
- Peristalsis
- Rats
- Rats, Inbred Strains
- Respiration
(drug effects)
- Transaminases
(blood)
- Tryptamines
(pharmacology, toxicity)
- Uterus
(drug effects)
|