Angiofollicular lymph node hyperplasia associated with myelofibrosis case report and immunologic marker studies.

Abstract

A case of angiofollicular lymph node hyperplasia (AFH) (hyaline vascular type) of the mediastinum associated with myelofibrosis is reported with immune marker studies. We hypothesize that the myelofibrosis is more than a mere coincidence since other myeloproliferative disorders have been observed in conjunction with AFH. Immunohistochemistry on cryostat sections of lymph node using the biotin-avidin fluorescence technique showed the presence of numerous T helper cells and very few T suppressor/cytotoxic cells in the parafollicular areas. Concentric rings of lymphocytes showed the phenotype of mantle zone lymphocytes (i.e. IgM, IgD positivity), while the germinal centres were ill-formed as shown by Leu 14 (a Pan B cell marker) staining. By electron microscopy, follicular dendritic reticulum cells were readily found. The above findings suggest an abnormality of germinal center formation.

• Authors: I J Bleiweiss, O L Dumitrescu, J Jagirdar
• Journal: Hematological oncology (Hematol Oncol) 1988 Oct-Dec Vol. 6 Issue 4 Pg. 275-84 ISSN: 0278-0232 [Print] England
• PMID: 2972599 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, Differentiation

Topics

• Antigens, Differentiation (analysis)
• Bone Marrow (pathology)
• Castleman Disease (immunology, pathology)
• Fluorescent Antibody Technique
• Humans
• Hyperplasia
• Lymph Nodes (immunology, pathology)
• Male
• Microscopy, Electron
• Middle Aged
• Primary Myelofibrosis (pathology)
• T-Lymphocytes, Helper-Inducer (pathology)