Transition Rate from EGFR-TKI to Cytotoxic Chemotherapy Patients with EGFR Mutation-positive Lung Adenocarcinoma.

Abstract

BACKGROUND/AIM:

The transition rate from first-line epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) to cytotoxic chemotherapy (Ct) is poor. The prognosis according to treatment sequence and the reasons patients could not shift from first-line EGFR-TKIs to Ct were herein analyzed.

PATIENTS AND METHODS:

Overall, 159 epidermal growth factor receptor mutation-positive adenocarcinoma patients were enrolled in this study.

RESULTS:

The median survival times of EGFR-TKIs combined with Ct and EGFR-TKIs were 59.8 months and 22.5 months, respectively (p<0.001) and of patients who received EGFR-TKIs first and Ct first were 38.8 months and 66.4 months, respectively (p=0.016). The main reasons patients could not make the transition to Ct was worsening of performance status and patient's preference.

CONCLUSION:

EGFR-TKIs and Ct lead to a good prognosis in EGFR mutation-positive adenocarcinoma patients. It is necessary to consider the timing when changing the treatment strategy before treatment options are limited.

• Authors: Yohei Kawaguchi, Tetsuya Okano, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
• Journal: Anticancer research (Anticancer Res) Vol. 38 Issue 5 Pg. 3127-3132 (05 2018) ISSN: 1791-7530 [Electronic] Greece
• PMID: 29715152 (Publication Type: Journal Article)
• Copyright: Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Antineoplastic Agents
• Protein Kinase Inhibitors
• EGFR protein, human
• ErbB Receptors

Topics

• Adenocarcinoma (drug therapy, genetics, mortality)
• Adenocarcinoma of Lung
• Adult
• Aged
• Antineoplastic Agents (therapeutic use)
• ErbB Receptors (genetics)
• Female
• Humans
• Kaplan-Meier Estimate
• Lung Neoplasms (drug therapy, genetics, mortality)
• Male
• Middle Aged
• Protein Kinase Inhibitors (therapeutic use)
• Retrospective Studies