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[Prophylactic efficacy of reaferon in viral hepatitis A and acute respiratory infections in children].

Abstract
Reaferon, the analog of human alpha 2-interferon obtained by gene engineering techniques, was studied with a view to its use for the prevention of hepatitis A. The study involved children of preschool age in Tashkent. In a strictly controlled trial children aged 2-6 years received the preparation orally in a dose of 1 X 10(6) I. U. or the diluent alone used as placebo. The preparation was administered to 1,100 children and the placebo to 1,078 children. The preparation and placebo were administered twice a week for two months. On the whole, during that period hepatitis A morbidity in both test and control groups of children was the same (5.1% and 4.9% respectively), but among children of nursery age receiving Reaferon the incidence of hepatitis A and acute respiratory viral infections was lower than among those receiving the placebo, though this difference was statistically significant only for cases of acute respiratory infections.
AuthorsA K Iuldashev, A N Slepushkin, M A Khodzhaeva, E I Schastnyĭ, F Kh Kamilov
JournalZhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 5 Pg. 65-9 (May 1988) ISSN: 0372-9311 [Print] Russia (Federation)
Vernacular TitleIzuchenie profilakticheskoĭ éffektivnosti reaferona pri virusnom gepatite A i ostrykh respiratornykh infektsiiakh u deteĭ.
PMID2970744 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Interferon Type I
  • Interferon alpha-2
  • Interferon-alpha
  • Placebos
  • Recombinant Proteins
Topics
  • Acute Disease
  • Child, Preschool
  • Drug Evaluation
  • Hepatitis A (epidemiology, prevention & control)
  • Humans
  • Infant
  • Interferon Type I (therapeutic use)
  • Interferon alpha-2
  • Interferon-alpha
  • Placebos
  • Recombinant Proteins (therapeutic use)
  • Respiratory Tract Infections (epidemiology, prevention & control)
  • Seasons
  • Time Factors
  • Uzbekistan

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