The effect of short term treatment with cyproterone acetate or flutamide on the metabolism of 5 alpha-dihydrotestosterone in human testicular tissue.

Abstract

Testicular tissue obtained from ten patients orchiectomized for prostatic cancer was incubated with [3H]5 alpha-dihydrotestosterone (DHT) in order to study the metabolic transformation into 5 alpha-androstane-3 alpha,17 beta-diol (3 alpha-diol) and 5 alpha-androstane-3 beta,17 beta-diol (3 beta-diol). Throughout 5 days before surgery four subjects were treated with cyproterone acetate (CA). To three patients flutamide (F) was administered for the same period of time. Three subjects remained untreated. Compared to the control group the administration of CA decreased the formation of 3 beta-diol whereas that of 3 alpha-diol increased. Treatment with F lead to an elevated formation of both diols. However, the 3 alpha/3 beta ratio did not change. As 3 beta-diol is considered to be an index of tubular function in the human testis it is concluded that CA has a direct inhibitory effect upon this testicular compartment whereas F has none.

• Authors: J Tamm, U Volkwein, F Donn
• Journal: Journal of steroid biochemistry (J Steroid Biochem) Vol. 31 Issue 2 Pg. 251-2 (Aug 1988) ISSN: 0022-4731 [Print] England
• PMID: 2970000 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anilides
• Dihydrotestosterone
• Cyproterone Acetate
• Flutamide
• Cyproterone

Topics

• Aged
• Aged, 80 and over
• Anilides (pharmacology)
• Cyproterone (analogs & derivatives, pharmacology)
• Cyproterone Acetate
• Dihydrotestosterone (metabolism)
• Flutamide (pharmacology)
• Humans
• Male
• Middle Aged
• Testis (drug effects, metabolism)