One of the main causes of
lower urinary tract symptoms in men over the age of 40 years old is
benign prostatic hyperplasia (BPH), which according to the research is detected in 26.2% of men of this age group. The purpose of this study was to evaluate the efficacy of the use of
silodosin (Urorec®) at dosage 8 mg once a day for relief of obstructive symptoms of BPH in men over 40 years old. From September 2016 till December 2017 144 men (residents of Almaty, the Republic of Kazakhstan) aged from 56 to 81 years old (63.9 [95% CI: 63.2, 64.5]) were included into the study with a diagnosis of
benign prostatic hyperplasia. Uroflowmetry (Qmax determination) was performed to all patients initially, after 7, 14, 30, 60 and 120 days from initiation of treatment. IPSS questionnaires were filled initially, after 30, 60 and 120 days from the start of treatment, and 21 men underwent a complex urodynamic study with determination of PdetQmax, Qmax and BOOI (at baseline and after 120 days). A significant decrease in
bladder outlet obstruction index was observed with
silodosin reception (Urorec®) 8 mg once daily (-28.8 [95% CI: -28.2, -29.5] or -44.5% [95% CI: -43.4%, - 45.5%] (p <0.001)), a decrease in IPSS scores after 30, 60 and 120 days from initiation of treatment (-6.3 [95% CI: -5.9, -6.7], -6.5 [95% CI: -6.1, - 6.9], -6.8 [95% CI: -6.4, -7.2] respectively (p <0.001)), an increase in Qmax after 7, 14, 30, 60 and 120 days from initiation of treatment (+1.1 mL/s [95% CI: 1.0 mL/s, 1.2 mL/s], +1.6 mL/s [95% CI: 1.5 mL/s, 1.7 mL/s], +2.4 mL/s [95% CI: 2.3 mL/s, 2.5 mL/s], +2.5 mL/s [95% CI: 2.4 mL/s, 2.6 mL/s], +2.5 mL/s [95% CI: 2.4 mL/s, 2.7 mL/s] respectively (p <0.001)). The data obtained in the study allow us to recommend
silodosin (Urorec®) at a dosage of 8 mg once a day as a first-line
drug for the pathogenetic treatment of
bladder outlet obstruction due to
benign prostatic hyperplasia.