| Abstract | The immunohistological features of rheumatoid nodules and rheumatoid synovium were examined using monoclonal and polyclonal antibodies raised against macrophages, HLA-DR, leucocyte common antigen, and immunoglobulin components. The palisading cells surrounding the necrotic centre of the rheumatoid nodule were shown to be HLA-DR positive leucocytes, mostly histiocytes. The inflammatory infiltrate associated with rheumatoid nodules showed many immunohistochemical similarities to that of rheumatoid synovium, including a preponderance of IgG positive plasma cells, and a similar number and microanatomical pattern of distribution of HLA-DR positive cells. The significance of these findings for the cellular immunopathology and aetiology of the rheumatoid lesion is discussed. |
| Authors | N A Athanasou, J Quinn, C G Woods, J O Mcgee
(Affiliation: Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital.)
|
| Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 47
Issue 5
Pg. 398-403
(May 1988)
ISSN: 0003-4967 ENGLAND |
| PMID | 2968782
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antigens, Differentiation
- HLA-DR Antigens
- Histocompatibility Antigens
- Antigens, CD45
|
| Topics |
- Antigens, CD45
- Antigens, Differentiation
(analysis)
- Arthritis, Rheumatoid
(immunology, pathology)
- HLA-DR Antigens
(analysis)
- Histocompatibility Antigens
(analysis)
- Humans
- Immunoenzyme Techniques
- Leukocytes
(pathology)
- Rheumatoid Nodule
(immunology, pathology)
- Synovial Membrane
(immunology, pathology)
|
