In forty-six sterile women,
endometriosis externa was diagnosed and classified laparoscopically. 21 patients were treated with
Gestrinone 5mg-10mg/week and 25 patients were treated with
Danazol 300mg-400mg/day for 6 months. The effects of these hormonal treatments were evaluated by second-look laparoscopy according to adhesion severity, number of blueberry spots and chocolate
cyst size, as well as
dysmenorrhea and other complaints. The results were as follows; 1)
Dysmenorrhea was relieved in 60.0% of the
Gestrinone-treated group and 45.5% of the
Danazol group. 2) Adhesion was weakened or partially separated spontaneously in 66.7% of the
Gestrinone group and 63.6% of the
Danazol group. 3) Blueberry spots decreased in number or paled in 61.9% of the
Gestrinone group and 75.0% of the
Danazol group. 4) Chocolate
cyst size became smaller in 60.0% of the
Gestrinone group and 77.8% of the
Danazol group. 5) Peritoneal fluid volume was not decreased after the hormonal treatments but the
prostaglandin E2 concentration in peritoneal fluid was decreased (p less than 0.05) after
Gestrinone therapy. 6) The patients complained of some side effects, liver function especially was disturbed in 48.0% of the
Danazol group and 9.5% of the
Gestrinone group.
Hoarseness was complained of in 33.3% of the
Gestrinone group and 12.0% of the
Danazol group. 7) Finally, 23.8% of the
Gestrinone group and 28.0% of the
Danazol group conceived after the hormonal treatments.