Genetics of susceptibility to 6-aminonicotinamide-induced cleft palate in the mouse: studies in congenic and recombinant inbred strains.

Abstract

In a search for genetic differences in susceptibility to cleft palate, congenic and recombinant inbred strains of mice were treated with 6-aminonicotinamide or control injections. Of six loci tested, only the chromosome segment marked by N-acetyl transferase was found to affect susceptibility to 6-aminonicotinamide-induced cleft palate. This chromosome segment is known to affect glucocorticoid-induced cleft palate and phenytoin-induced cleft lip with or without cleft palate in these strains of mice.

• Authors: J Karolyi, R P Erickson, S Liu
• Journal: Teratology (Teratology) Vol. 37 Issue 3 Pg. 283-7 (Mar 1988) ISSN: 0040-3709 [Print] United States
• PMID: 2966993 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Niacinamide
• 6-Aminonicotinamide

Topics

• 6-Aminonicotinamide (adverse effects)
• Abnormalities, Drug-Induced (etiology)
• Animals
• Cleft Palate (chemically induced)
• Female
• Male
• Mice
• Mice, Inbred Strains (genetics)
• Niacinamide (analogs & derivatives)
• Pregnancy
• Recombination, Genetic (drug effects)