rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1.

Abstract

The Rpt-1 (for regulatory protein, T-lymphocyte, 1) gene, selectively expressed by resting but not by activated CD4+ inducer T cells, encodes an intracellular protein (rpt-1, Mr 41,000) that down-regulates gene expression directed by the promoter region of the gene encoding interleukin 2 receptor alpha chain and by the long terminal repeat of human immunodeficiency virus type 1. The data reported here suggest that rpt-1 levels may be inversely correlated with activation of CD4+ T cells and human immunodeficiency virus replication leading to clinical symptoms of the acquired immunodeficiency syndrome.

• Authors: R Patarca, G J Freeman, J Schwartz, R P Singh, Q T Kong, E Murphy, Y Anderson, F Y Sheng, P Singh, K A Johnson
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 85 Issue 8 Pg. 2733-7 (Apr 1988) ISSN: 0027-8424 [Print] United States
• PMID: 2965815 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA-Binding Proteins
• Receptors, Immunologic
• Receptors, Interleukin-2
• Transcription Factors
• Trim30a protein, mouse

Topics

• Acquired Immunodeficiency Syndrome (physiopathology)
• Amino Acid Sequence
• Animals
• Base Sequence
• Cell Line
• DNA-Binding Proteins (physiology)
• Gene Expression Regulation
• Genes
• Genes, Regulator
• Genes, Viral
• HIV (genetics)
• Humans
• Lymphocyte Activation
• Mice
• Molecular Sequence Data
• Promoter Regions, Genetic
• Protein Conformation
• Receptors, Immunologic (genetics)
• Receptors, Interleukin-2
• T-Lymphocytes, Helper-Inducer (physiology)
• Transcription Factors (physiology)