L3T4+ T cells regulate Abelson virus-induced lymphomagenesis.

Abstract

To evaluate the role of T cells in regulation of lymphomagenesis, experiments were performed using Abelson murine leukemia virus (AMuLV). In vitro transformation of bone marrow target cells by this B lymphotropic retrovirus was inhibited by peripheral lymph node cells from naive mice. The inhibitory activity depended on Thy-1+ L3T4+ cells but did not require Lyt-2+ cells. In vivo depletion of L3T4+ T cells with a mAb (GK1.5) altered the course of AMuLV-induced lymphoma. L3T4 depletion of naturally resistant C57BL/6 mice resulted in dramatic susceptibility to lymphoma induction. Lymphoma cells from anti-L3T4-treated C57BL/6 mice infected with AMuLV displayed the B lineage transformation marker P1606C3. These studies reveal an important immunologic component of Abelson disease resistance involving L3T4+ T cells.

• Authors: A J Infante, S Boulware, M Cagle
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 140 Issue 7 Pg. 2462-5 (Apr 01 1988) ISSN: 0022-1767 [Print] United States
• PMID: 2965186 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Differentiation, T-Lymphocyte
• Antigens, Neoplasm

Topics

• Abelson murine leukemia virus (immunology)
• Animals
• Antigens, Differentiation, T-Lymphocyte
• Antigens, Neoplasm (analysis)
• Bone Marrow Cells
• Cell Transformation, Neoplastic (immunology)
• Cell Transformation, Viral
• Leukemia, Experimental (immunology)
• Lymphocyte Depletion
• Lymphoma (immunology)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Phenotype
• T-Lymphocytes, Regulatory (classification, immunology)