[Treatment of neonatal infections: the place of cephalosporins].

Abstract

The most commonly used antibiotic combination as a first-line treatment in neonates is ampicillin and an aminoglycoside. The increasing resistance of E. coli to ampicillin requires another choice. Good activity against group B Streptococci and E. coli, good CSF penetration and fewer side-effects are in favour of third generation cephalosporins as part of the antibiotic therapy. If a Listeria infection has not been excluded at the beginning of treatment, a triple combination may be given: ampicillin + third generation cephalosporin + aminoglycoside during the first 48 hours. The prognosis of enterobacterial meningitis has improved with third generation cephalosporins. As the other beta-lactam antibiotics, they modify the intestinal microbial ecosystem.

• Authors: Y Aujard
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 16 Issue 43 Pg. 2176-9 (Dec 16 1987) ISSN: 0755-4982 [Print] France
• Vernacular Title: Traitement des infections néonatales: place des céphalosporines.
• PMID: 2963307 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Cephalosporins

Topics

• Bacterial Infections (drug therapy, metabolism)
• Cephalosporins (administration & dosage, pharmacokinetics, therapeutic use)
• Drug Therapy, Combination
• Humans
• Infant, Newborn
• Time Factors