Abstract |
The hyperosmolarity-induced response of the ocular standing potential (SP) provides a method of testing the function of the retinal pigment epithelium (RPE) without using light stimulation. In this study, the changes in potential level occurring after a short-term intravenous injection of 10 ml of 20% mannitol were determined by means of a direct current amplifier for the following groups: Group 1, normal rabbit eyes; Group 2, rabbit eyes in which the RPE was damaged by sodium iodate; Group 3, rabbit eyes in which the photoreceptors were damaged by monoiodoacetic acid; Group 4, rabbit eyes with uveoretinitis experimentally induced by Arthus-type inflammation. The following results were obtained: 1. The hyperosmolarity-induced SP response consisted of a transient increase in potential level (positive wave) in Group 1. 2. For Group 2 a transient decrease in potential level (negative wave) was obtained, i.e., a reversal of the normal positive response to negative wave. 3. A positive wave and no reversal was found for Group 3. 4. For Group 4 a negative wave and a reversal of the normal response was obtained. These hyperosmolarity-induced SP responses provide additional information concerning the possibilities of the method for studying the function of the RPE.
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Authors | M Yamada, E Suzuki, G Kikuchi, J Hamazaki, S Hamazaki, H Matsuo |
Journal | Documenta ophthalmologica. Advances in ophthalmology
(Doc Ophthalmol)
Vol. 66
Issue 4
Pg. 347-58
(Aug 1987)
ISSN: 0012-4486 [Print] Netherlands |
PMID | 2962841
(Publication Type: Journal Article)
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Chemical References |
- Iodates
- Iodoacetates
- Mannitol
- sodium iodate
- Iodoacetic Acid
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Topics |
- Aging
(physiology)
- Animals
- Arthus Reaction
(complications)
- Electrophysiology
- Electroretinography
- Iodates
(pharmacology)
- Iodoacetates
(pharmacology)
- Iodoacetic Acid
- Mannitol
(pharmacology)
- Ocular Physiological Phenomena
- Osmolar Concentration
- Rabbits
- Retinitis
(etiology, physiopathology)
- Uveitis
(etiology, physiopathology)
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