Abstract |
A role of CD4+ T helper cells in induction of tumor transplant rejection leading to complete regression of a highly metastatic DBA/2 mouse lymphoma was analyzed. Using an anti-CD4 monoclonal antibody (GK1.5) which eliminates T helper cells in vivo and in vitro, we found that CD4+ cells are required for tumor resistance in syngeneic DBA/2 mice or allogeneic but major histocompatibility complex-identical B10.D2 mice. In contrast, in allogeneic C57BL/6 mice tumor rejection was independent of CD4+ cells. An analogous requirement for immune CD4+ cells for in vitro induction of CD8+ tumor-specific cytotoxic T cells was found in these respective strains. The requirement for immune CD4+ cells in vitro could be replaced by recombinant interleukin 2. These results demonstrate a role of CD4+ regulatory T cells and T-T cell cooperation in the induction of anti- tumor immunity and tumor rejection, and point to possible therapeutic interventions in the afferent phase of anti- tumor immune responses.
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Authors | H J Schild, B Kyewski, P Von Hoegen, V Schirrmacher |
Journal | European journal of immunology
(Eur J Immunol)
Vol. 17
Issue 12
Pg. 1863-6
(Dec 1987)
ISSN: 0014-2980 [Print] Germany |
PMID | 2961578
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Cells, Cultured
- Graft Rejection
- In Vitro Techniques
- Interleukin-2
(pharmacology)
- Lymphocyte Cooperation
- Lymphoma
(immunology)
- Mice
- Mice, Inbred Strains
- Neoplasm Metastasis
- Neoplasm Transplantation
- Neoplasms, Experimental
(immunology)
- T-Lymphocytes, Cytotoxic
(immunology)
- T-Lymphocytes, Helper-Inducer
(immunology)
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