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CD4+ helper T cells are required for resistance to a highly metastatic murine tumor.

Abstract
A role of CD4+ T helper cells in induction of tumor transplant rejection leading to complete regression of a highly metastatic DBA/2 mouse lymphoma was analyzed. Using an anti-CD4 monoclonal antibody (GK1.5) which eliminates T helper cells in vivo and in vitro, we found that CD4+ cells are required for tumor resistance in syngeneic DBA/2 mice or allogeneic but major histocompatibility complex-identical B10.D2 mice. In contrast, in allogeneic C57BL/6 mice tumor rejection was independent of CD4+ cells. An analogous requirement for immune CD4+ cells for in vitro induction of CD8+ tumor-specific cytotoxic T cells was found in these respective strains. The requirement for immune CD4+ cells in vitro could be replaced by recombinant interleukin 2. These results demonstrate a role of CD4+ regulatory T cells and T-T cell cooperation in the induction of anti-tumor immunity and tumor rejection, and point to possible therapeutic interventions in the afferent phase of anti-tumor immune responses.
AuthorsH J Schild, B Kyewski, P Von Hoegen, V Schirrmacher
JournalEuropean journal of immunology (Eur J Immunol) Vol. 17 Issue 12 Pg. 1863-6 (Dec 1987) ISSN: 0014-2980 [Print] Germany
PMID2961578 (Publication Type: Journal Article)
Chemical References
  • Interleukin-2
Topics
  • Animals
  • Cells, Cultured
  • Graft Rejection
  • In Vitro Techniques
  • Interleukin-2 (pharmacology)
  • Lymphocyte Cooperation
  • Lymphoma (immunology)
  • Mice
  • Mice, Inbred Strains
  • Neoplasm Metastasis
  • Neoplasm Transplantation
  • Neoplasms, Experimental (immunology)
  • T-Lymphocytes, Cytotoxic (immunology)
  • T-Lymphocytes, Helper-Inducer (immunology)

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