Multi-centre open study of a triphasic levonorgestrel-ethinyloestradiol combined oral contraceptive ('Trinordiol').

Abstract

A long-term, multi-centre open study was carried out to evaluate the efficacy, cycle control and side-effects with a triphasic, combined oral contraceptive containing levonorgestrel and ethinyloestradiol ('Trinordiol'). A total of 2517 women completing at least 1 cycle of treatment was followed up at 2 to 3-monthly intervals; the overall number of cycles on treatment was 37,090. During treatment, only 2 pregnancies occurred which were attributable to pill failure. Cycle control was good: cycle irregularities were 9.6% overall, but were most common (19.6%) during the first 3 cycles. Only 3.8% of patients withdrew from the study for this reason. Side-effects were those commonly seen with oral contraceptives, and they produced a drop-out rate of only 13.9%. There were no clinically significant effects on blood pressure or body weight. The results also suggested that 'Trinordiol' has a beneficial effect on pre-existing acne.

• Authors: A J Butler, A Green, M Cohen
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 10 Issue 8 Pg. 503-13 ( 1987) ISSN: 0300-7995 [Print] England
• PMID: 2960493 (Publication Type: Journal Article)

Chemical References

• Contraceptives, Oral, Combined
• Contraceptives, Oral, Sequential
• Norgestrel
• Ethinyl Estradiol
• Ethinyl Estradiol-Norgestrel Combination

Topics

• Acne Vulgaris (drug therapy)
• Adolescent
• Adult
• Blood Pressure (drug effects)
• Body Weight (drug effects)
• Contraceptives, Oral, Combined (adverse effects)
• Contraceptives, Oral, Sequential (adverse effects)
• Ethinyl Estradiol (administration & dosage, adverse effects, pharmacology)
• Ethinyl Estradiol-Norgestrel Combination
• Female
• Follow-Up Studies
• Humans
• Menstrual Cycle (drug effects)
• Norgestrel (administration & dosage, adverse effects, pharmacology)